Cloning and characterization of cDNAs coding for heavy and light chains of a monoclonal antibody(MabA34) specific for human plasma apolipoprotein A-I

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Title
Cloning and characterization of cDNAs coding for heavy and light chains of a monoclonal antibody(MabA34) specific for human plasma apolipoprotein A-I
Author(s)
Ju Won Kwak; Dong-Ik Lee; Byung-Kwon Choi; Won Kyung Cho; Sang-Han Lee; Yong-Bok Park; Moon Hi Han
Bibliographic Citation
Gene, vol. 173, no. 2, pp. 257-259
Publication Year
1996
Abstract
We have determined the nucleotide (nt) sequences encoding the heavy (H)- and light (L)-chains of the Fab fragment of a murine monoclonal antibody, MabA34 (γl, κ), which is specific for human plasma apolipoprotein A-I of high-density lipoproteins. The variable (V) regions of the H- and L-chains were revealed to be members of mouse I-I-chain subgroup II(A) and κ L-chain subgroup II, respectively. A few unusual amino acids in the V region of the H-chain, and nt residues probably introduced by somatic mutations from germline genes were also identified.
Keyword
Apo A-IDNA sequencingHDL cholesterolhigh-density lipoproteinsimmunoglobulin Fabpolymerase chain reactionrecombinant DNA
ISSN
0378-1119
Publisher
Elsevier
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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