DC Field | Value | Language |
---|---|---|
dc.contributor.author | Joo Hyun Kang | - |
dc.contributor.author | Myung Kyu Lee | - |
dc.contributor.author | Kil Lyong Kim | - |
dc.contributor.author | Kyung Soo Hahm | - |
dc.date.accessioned | 2017-04-19T08:45:20Z | - |
dc.date.available | 2017-04-19T08:45:20Z | - |
dc.date.issued | 1996 | - |
dc.identifier.issn | 1039-9712 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/3711 | - |
dc.description.abstract | Synthetic pulmonary surfactants consisting of a mixture of phospholipids with synthetic peptides based on human and bovine surfactant-associated protein SP-B were prepared. These surfactants were analyzed for their biophysical activities by Wilhemly balance experiments and for their secondary structures by circular dichroism (CD) spectroscopy. Four synthetic peptides (SP-1, SP-2, SP-3, and SP-4) combined with the phospholipid mixture displayed significant surfactant properties. The CD spectra showed that the α-helical propensities of the peptides in SDS micelles were related to their surfactant activities. These results suggested that the several truncated peptides originated from SP-B protein, when appropriately recombined with phospholipids, could be used as an effective synthetic surfactant for clinical use. | - |
dc.publisher | Wiley | - |
dc.title | The relationships between biophysical activity and the secondary structure of synthetic peptides from the pulmonary surfactant protein SP-B | - |
dc.title.alternative | The relationships between biophysical activity and the secondary structure of synthetic peptides from the pulmonary surfactant protein SP-B | - |
dc.type | Article | - |
dc.citation.title | Biochemistry and Molecular Biology International | - |
dc.citation.number | 3 | - |
dc.citation.endPage | 627 | - |
dc.citation.startPage | 617 | - |
dc.citation.volume | 40 | - |
dc.contributor.affiliatedAuthor | Joo Hyun Kang | - |
dc.contributor.affiliatedAuthor | Myung Kyu Lee | - |
dc.contributor.affiliatedAuthor | Kil Lyong Kim | - |
dc.contributor.affiliatedAuthor | Kyung Soo Hahm | - |
dc.contributor.alternativeName | 강주현 | - |
dc.contributor.alternativeName | 이명규 | - |
dc.contributor.alternativeName | 김길룡 | - |
dc.contributor.alternativeName | 함경수 | - |
dc.identifier.bibliographicCitation | Biochemistry and Molecular Biology International, vol. 40, no. 3, pp. 617-627 | - |
dc.identifier.doi | 10.1080/15216549600201213 | - |
dc.description.journalClass | Y | - |
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