The relationships between biophysical activity and the secondary structure of synthetic peptides from the pulmonary surfactant protein SP-B

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dc.contributor.authorJoo Hyun Kang-
dc.contributor.authorMyung Kyu Lee-
dc.contributor.authorKil Lyong Kim-
dc.contributor.authorKyung Soo Hahm-
dc.date.accessioned2017-04-19T08:45:20Z-
dc.date.available2017-04-19T08:45:20Z-
dc.date.issued1996-
dc.identifier.issn1039-9712-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/3711-
dc.description.abstractSynthetic pulmonary surfactants consisting of a mixture of phospholipids with synthetic peptides based on human and bovine surfactant-associated protein SP-B were prepared. These surfactants were analyzed for their biophysical activities by Wilhemly balance experiments and for their secondary structures by circular dichroism (CD) spectroscopy. Four synthetic peptides (SP-1, SP-2, SP-3, and SP-4) combined with the phospholipid mixture displayed significant surfactant properties. The CD spectra showed that the α-helical propensities of the peptides in SDS micelles were related to their surfactant activities. These results suggested that the several truncated peptides originated from SP-B protein, when appropriately recombined with phospholipids, could be used as an effective synthetic surfactant for clinical use.-
dc.publisherWiley-
dc.titleThe relationships between biophysical activity and the secondary structure of synthetic peptides from the pulmonary surfactant protein SP-B-
dc.title.alternativeThe relationships between biophysical activity and the secondary structure of synthetic peptides from the pulmonary surfactant protein SP-B-
dc.typeArticle-
dc.citation.titleBiochemistry and Molecular Biology International-
dc.citation.number3-
dc.citation.endPage627-
dc.citation.startPage617-
dc.citation.volume40-
dc.contributor.affiliatedAuthorJoo Hyun Kang-
dc.contributor.affiliatedAuthorMyung Kyu Lee-
dc.contributor.affiliatedAuthorKil Lyong Kim-
dc.contributor.affiliatedAuthorKyung Soo Hahm-
dc.contributor.alternativeName강주현-
dc.contributor.alternativeName이명규-
dc.contributor.alternativeName김길룡-
dc.contributor.alternativeName함경수-
dc.identifier.bibliographicCitationBiochemistry and Molecular Biology International, vol. 40, no. 3, pp. 617-627-
dc.identifier.doi10.1080/15216549600201213-
dc.description.journalClassY-
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