Benzastatins A, B, C and D : new free radical scavengers from Streptomyces nitrosporeus 30643 I. taxonomy, fermentation, isolation, physico-chemical properties and biological activities

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Title
Benzastatins A, B, C and D : new free radical scavengers from Streptomyces nitrosporeus 30643 I. taxonomy, fermentation, isolation, physico-chemical properties and biological activities
Author(s)
Won Gon KimJong Pyung Kim; Chang Jin Kim; K H Lee; Ick Dong Yoo
Bibliographic Citation
Journal of Antibiotics, vol. 49, no. 1, pp. 20-25
Publication Year
1996
Abstract
In the course of screening for free radical scavengers, rare metabolites, benzastatins A and B having aminobenzamide skeleton, and benzastatins C and D having tetrahydroquinoline skeleton, were isolated from the culture broth of Streptomyces nitrosporeus 30643. They showed inhibitory activity against lipid peroxidation in rat liver microsomes. In the cell assay, benzastatins C and D inhibited glutamate toxicity in N18-RE-105 cells with EC50 values of 2.0 and 5.4 μM, respectively.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.7164/antibiotics.49.20
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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