Cytotoxic benzyl dihydroflavonols from Cudrania tricuspidata

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Title
Cytotoxic benzyl dihydroflavonols from Cudrania tricuspidata
Author(s)
In Kyoung Lee; Chang Jin Kim; K S Song; Hwan Mook Kim; H Koshino; M Uramoto; Ick Dong Yoo
Bibliographic Citation
Phytochemistry, vol. 41, no. 1, pp. 213-216
Publication Year
1996
Abstract
Three new dihydroflavonols, gericudranins A-C were isolated from the stem bark of Cudrania tricuspidata. They were identified as 6,8-di-p-hydroxybenzyltaxifolin, 8-p-hydroxybenzyltaxifolin and 6-p-hydroxybenzyltaxifolin, respectively, by means of spectral studies. These compounds were cytotoxic to human tumor cell lines, such as CRL 1579 (skin), LOX-IMVI (skin), MOLT-4F (leukemia), KM12 (colon) and UO-31 (renal) in culture, with ED50 values of 2.7-31.3 μg ml-1.
Keyword
6,8-di-p-hydroxybenzyltaxifolin6-p-hydroxybenzyltaxifolin8-p-hydroxybenzyltaxifolincudrania tricuspidatacytotoxicitydihydroflavonolsgericudraninsmoraceaeP-hydroxybenzyldihydroflavonolsstem bark
ISSN
0031-9422
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/0031-9422(95)00609-5
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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