Sesquiterpene O-naphthoquinones from the root bark of Ulmus davidiana

Abstract

Three new sesquiterpene ortho-naphthoquinones, davidianones A, B and C, together with four known compounds, mansonones E, F, H and I, were isolated from the root bark of Ulmus davidiana. On the basis of spectral data including pulse field gradient two-dimensional NMR spectroscopy, the structures of new compounds were established as 3-hydroxymethyl-6,9- dimethylnaphtho(1,8-b,c)pyran-7,8-dione, 6-methoxycarbonyl-3,9- dimethylnaphtho(1.8-b,c)pyran-7,8-dione, 6-dimethoxymethyl-3,9- dimethylnaphtho(1,8-b,c)pyran-7,8-dione, respectively. Their antioxidative activities were evaluated by a thiobarbituric acid method using rat liver microsomes, with mansonone F showing the greatest activity.