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- Title
- New anthracycline metabolites produced by the aklavinone 11-hydroxylase gene in Streptomyces galilaeus ATCC 31133
- Author(s)
- Hang Sub Kim; Young Soo Hong; Young Ho Kim; O J Yoo; Jung Joon Lee
- Bibliographic Citation
- Journal of Antibiotics, vol. 49, no. 4, pp. 355-360
- Publication Year
- 1996
- Abstract
- Transformation of Streptomyces galilaeus ATCC 31133 with the aklavinone 11-hydroxylase gene (dnrF) resulted in the production of many red pigments. The new metabolites were purified and their structures were determined as 11-hydroxylated aclacinomycin A, B and T by spectral analysis. This result indicated that the dnrF was stably expressed in the strain S. galilaeus ATCC 31133 to give rise to hybrid aclacinomycins. In addition, a new aclacinomycin analog named 11-hydroxyaclacinomycin X was isolated from the same culture. Its structure was elucidated as 2'''-amino-11-hydroxyaclacinomycin Y. It showed strong cytotoxicity against several human tumor cell lines, especially leukemia and melanoma cell lines.
- ISSN
- 0021-8820
- Publisher
- Springer-Nature Pub Group
- DOI
- http://dx.doi.org/10.7164/antibiotics.49.355
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
- Files in This Item:
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