Inhibition of phospholipase Cγ1 activity by amentoflavone isolated from Selaginella tamariscina

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Title
Inhibition of phospholipase Cγ1 activity by amentoflavone isolated from Selaginella tamariscina
Author(s)
Hyun Sun Lee; Won Keun Oh; Bo Yeon Kim; Soon Cheol Ahn; Dae Ook Kang; Dong In Shin; Jinwoong Kim; Tae Ick MheenJong Seog Ahn
Bibliographic Citation
Planta Medica, vol. 62, no. 4, pp. 293-296
Publication Year
1996
Abstract
Amentoflavone was isolated as an inhibitor of phospholipase Cγ1 (PLCγ1) and phosphoinositides (PI)-turnover in PLCγ1 overexpressing NIH3T3 fibroblasts (NIH3T3γ1) from Selaginella tamariscina (Selaginellaceae) together with other related biflavonoids, isocryptomerin and cryptomerin B. Only amentoflavone inhibited the PLCγ1 activity with an IC50 of 29 μM and the formation of total inositol phosphates (IP(t) in PDGF-stimulated NIH3T3γ1 with an IC50 of 9.2 μM but did not show inhibitory activity against protein kinase C. Isocryptomerin and cryptomerin B did not show inhibitory activity against PLCγ1 at the concentration of 150 μ M, and did not inhibit IP(t) production in PDGF-induced NIH3T3γ1 at the concentration of 180 μM.
Keyword
amentoflavonekampo medicinesphosphoinositides (PI)-turnoverphospholipase Cγ1 inhibitorselaginella tamariscinaselaginellaceae
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2006-957887
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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