Solandelactones A-I, lactonized cyclopropyl oxylipins isolated from the hydroid Solanderia secunda

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Title
Solandelactones A-I, lactonized cyclopropyl oxylipins isolated from the hydroid Solanderia secunda
Author(s)
Youngwan Seo; Ki Woong Cho; Jung-Rae Rho; Jongheon Shin; Byoung-Mog Kwon; Song Hae Bok; Jun-Im Song
Bibliographic Citation
Tetrahedron, vol. 52, no. 32, pp. 10583-10596
Publication Year
1996
Abstract
Solandelactones A-I(1-9), cyclopropyl and lactone containing novel docosanoids have been isolated from the hydroid Solanderia secunda. The structure of these compounds have been elucidated by combined spectral and chemical studies. Configuration of the cyclopropyl ring has been essigned as the opposite of related oxylipins by NOESY experiments. Absolute stereochemistry has been determined on the basis of chemical transformations and CD measurements of synthetic derivatives. In addition, the biogenetic origin of solandelactones has been discussed. Solandelactones C, D and G exhibited moderate inhibitory activity against Farnesyl Protein Transferase.
ISSN
0040-4020
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/0040-4020(96)00606-0
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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