Amplification of farnesyl protein transferase inhibitory activity from Aspergillus fumigatus F93 by Plackett-Burman design

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Title
Amplification of farnesyl protein transferase inhibitory activity from Aspergillus fumigatus F93 by Plackett-Burman design
Author(s)
Kwang Hee Son; Young-Kook Kim; Hyun Woo Lee; Woo-Sang Lee; Sung Uk Kim; Tae Sook Jeong; Byoung-Mog Kwon; Song Hae Bok
Bibliographic Citation
Biotechnology Letters, vol. 18, no. 11, pp. 1297-1300
Publication Year
1996
Abstract
Fermentation optimization for the fungus Aspergillus fumigatus F93 was performed to amplify the most promising biological activity. Twelve active variables were analysed and optimized by the Plackett-Burman design, consisting of 16 experiments. Farnesyl protein transferase inhibitory activity showed the best response for the design, and selected parameters were confirmed by separate experiments in the optimized fermentation condition.
ISSN
0141-5492
Publisher
Springer
DOI
http://dx.doi.org/10.1007/BF00129958
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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