Lipid peroxidation inhibitors from Polyozellus multiplex = Polyozellus multiplex가 생산하는 지질과산화 저해물질

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Title
Lipid peroxidation inhibitors from Polyozellus multiplex = Polyozellus multiplex가 생산하는 지질과산화 저해물질
Author(s)
Ji Sook Hwang; Kyung-Sik Song; Yang-Sup Kim; Soon-Ja Seok; Tae-Ho Lee; Ick Dong Yoo
Bibliographic Citation
Korean Journal of (Applied) Microbiology & Biotechnology, vol. 24, no. 5, pp. 591-596
Publication Year
1996
Abstract
In the course of screening lipid peroxidation inhibitor from basidiomycetes, a mushroom, which was collected at O-Dae mountain in KangweonDo, was found to have active compound. The mushroom was identified as Polyzellus multiplex, which belongs to Aphylloporalles Thelephoraceae, on the basis of macroscopic and microscopic characteristics of the fruiting body. The methanol extract of fruiting body was extracted with benzene and ethylacetate, sequentially. By using various kinds of chromatographies, PM1, and PM2 and PM3, were purified from the ethylacetate extract and the benzene extract, respectively. Color reaction and analyses of IR, UV, and NMR spectra indicated that PM1 was a derivative of thelephoric acid, and PM2 and PM3 were linoleic acid and oleic acid, respectively. IC50 of PM1 for inhibition of lipid peroxidation was 1.96 ppm and LD50 was 500 mg/kg.
Keyword
basidiomyceteslinoleic acidlipid peroxidation inhibitoroleic acidpolyozellus multiplexthelephoric acid derivative
ISSN
0257-2389
Publisher
Korea Soc-Assoc-Inst
Type
Article
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1. Journal Articles > Journal Articles
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