Structure determination and biological activities of elaiophylin produced by Streptomyces sp. MCY-846

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Title
Structure determination and biological activities of elaiophylin produced by Streptomyces sp. MCY-846
Author(s)
S Y Lee; Mi Soon Kim; Hang Sub Kim; Young Ho Kim; S D Hong; Jung Joon Lee
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 6, no. 4, pp. 245-249
Publication Year
1996
Abstract
A cytotoxic compound, 846I was isolated from the culture of Streptomyces sp. strain MCY846 by its cytotoxicity against gastric cancer cell line SNU-1. The IR, UV and NMR spectra of 846I were identical to those of elaiophylin. This compound showed moderate cytotoxicity against several cell lines and exerted strong inhibitory effect on the synthesis of nitric oxide in the lipopolysaccharide stimulated-Raw 264.7 cells.
Keyword
antibacterial activitycytotoxicityelaiophylinnitric oxide
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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