Metabolism of glycyrrhizin and baicalin by human intestinal bacteria

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Title
Metabolism of glycyrrhizin and baicalin by human intestinal bacteria
Author(s)
Dong-Hyun Kim; Il-Sung Jang; Hyeong Kyu Lee; Eun-Ah Jung; Kyeu-Yup Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 19, no. 4, pp. 292-296
Publication Year
1996
Abstract
By human intestinal bacteria, glycyrrhizin (18β-glycyrrhetic acid β-D-glucuronyl α-D-glucuronic acid, GL) and baicalin (baicalein β-D-glucuronic acid) were metabolized to glycyrrhetinic acid and baicalin, respectively. However, α-glucuronidase of Bacteroides JY-6 isolated from human intestinal bacteria hydrolyzed GL or 18β-glycyrrhetinic acid α-D-glucuronic acid to 18β-glycyrrhetic acid but did not baicalin. However, E coli β-glucuronidase from human intestinal bacteria hydrolyzed baicalin to baicalein, but did not GL. β-Glucuronidase of mammalian tissues hydrolyzed both GL and baicalin.
Keyword
bacteroides J-37baicalinglycyrrhizinintestinal bacteria
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02976243
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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