Cytotoxicity of trichothecenes to human solid tumor cells In vitro

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Title
Cytotoxicity of trichothecenes to human solid tumor cells In vitro
Author(s)
Sang Un Choi; Eun Jung Choi; Kwang Hee Kim; Nam Young Kim; Byoung-Mog Kwon; Sung Uk Kim; Song Hae Bok; So Young Lee; Chong Ock Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 19, no. 1, pp. 6-11
Publication Year
1996
Abstract
The trichothecenes are sesquiterpenoid mycotoxins characterized by the 12,13-epoxytrichothec-9-ene ring system. We have tested cytotoxicity of several naturally-occurring or synthesized trichothecenes against human solid tumor cell lines. Among them, trichothecin (I) and 4-β-Acetoxy-12,13-epoxytrichothec-9-ene (trichodermin, II) exhibited highly cytotoxic activities. 4-β-Hydroxy-12,13-epoxytrichothec-9-ene (trichodermol, III) and 4-β-Methoxy-12,13-epoxytrichothec-9-ene (IV) had mild cytotoxicities. But 12,13-Epoxytrichothec-9-ene-4-one (V) and 4-α-Hydroxy-12,13-epoxytrichothec-9-ene(VI) had no cytotoxicities up to 10 μg/ml. And in the tested cell lines, HCT15 colon cancer cell line was the most sensitive to all tested trichothecenes.
Keyword
CytotoxicityGliocladiumHuman tumor cell lineTrichothecenesTrichothecium
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02976812
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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