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- Title
- Isolation and characterization of antifungal compound produced by Aspergillus candidus F1484 = Aspergillus candidus F1484 균주가 생산하는 항진균 화합물의 분리 및 특성
- Author(s)
- Sung Uk Kim; So Young Lee; Sung Kyu Kim; Kwang Hee Son; Young Kook Kim; S S Moon; Song Hae Bok
- Bibliographic Citation
- Korean Journal of (Applied) Microbiology & Biotechnology, vol. 24, no. 5, pp. 574-578
- Publication Year
- 1996
- Abstract
- In the course of screening for the antifungal compounds against Candida albicans, an antifungal compound (F1480) was isolated from the culture broth of Aspergillus candidus F1484. Isolation and purification of compound F1484 were performed using ethyl acetate extraction, silica gel column chromatography, ODS column chromatography, and preparative HPLC. The structure of compound F1484 was determined by the spectroscopic analyses of EI-MS, 13C-, 1H-NMR, DEPT, HMQC, and HMBC. This compound appeared to have a structure of antifungal agent, chloroflavonin. In addition to antifungal activities against the yeast phase of Candida species, compound F1484 showed cytotoxic effect against various human tumor cell lines.
- Keyword
- antifungal activityC. albicanscytotoxicitydimorphism
- ISSN
- 0257-2389
- Publisher
- Korea Soc-Assoc-Inst
- Type
- Article
- Appears in Collections:
- Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
- Files in This Item:
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