Comparative pharmacokinetics and tissue distribution of Norfloxacin-glycine acetate in flounder, (Paralichthys olivaceus) at two different temperatures

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Title
Comparative pharmacokinetics and tissue distribution of Norfloxacin-glycine acetate in flounder, (Paralichthys olivaceus) at two different temperatures
Author(s)
S C Park; H I Yoon; Tae Kwang Oh
Bibliographic Citation
Journal of Veterinary Medical Science, vol. 58, no. 10, pp. 1039-1040
Publication Year
1996
Abstract
The pharmacokinetics of norfloxacin-glycine acetate (NFXGA), a newly formulated norfloxacin, was investigated in healthy flounders at two different seawater temperature (at 12°C and 20°C) varying concentrations (100 ppm and 10 ppm), using dipping administration. It was shown that the elimination half-life (T1,2) of norfloxacin at 20°C (10 ppm: 13.95 ± 1.18 hr, 100 ppm: 11.71 ± 1.32 hr) was significantly shorter than that at 12°C (10 ppm: 16.61 ± 1.47 hr, 100 ppm: 16.32 ± 1.19 hr) in flounders. Mean residence time (MRT) was calculated at 12°C (10 ppm: 194.87 ± 29.88 hr, 100 ppm: 1,222.37 ± 161.45 hr) and 20°C (10 ppm: 168.42 ± 25.85, 100 ppm: 606.14 ± 122.75 hr). Meanwhile, in the flounder tissue distribution of norfloxacin. It was shown that serum, muscle, kidney, and liver exhibited different elimination half-lives of norfloxacin.
Keyword
FlounderNorfloxacinPharmacokinetics
ISSN
0916-7250
Publisher
Japan Soc Vet Sci
DOI
http://dx.doi.org/10.1292/jvms.58.10_1039
Type
Article
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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