Metabolites and amino acids affecting cellular cofactor concentrations and poly-β-hydroxybutyrate biosynthesis in Alcaligenes eutrophus

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Title
Metabolites and amino acids affecting cellular cofactor concentrations and poly-β-hydroxybutyrate biosynthesis in Alcaligenes eutrophus
Author(s)
Mi Kyung Kim; In Young Lee; Young Hoon Park
Bibliographic Citation
Biotechnology Letters, vol. 18, no. 5, pp. 559-564
Publication Year
1996
Abstract
Additon of pyruvate or leucine was found to be efficient for increasing the intracellular ratios of NADH/NAD and NADPH/NADP while reducing the coenzyme A concentration during the cultivation of Alcaligenes eutrophus. Poly- β -hydroxybutyrate (PHB) accumulation was enhanced more than 2-fold since metabolic flux of acetyl-CoA into PHB synthetic pathway could be facilitated by the changes of the cofactor concentrations.
ISSN
0141-5492
Publisher
Springer
DOI
http://dx.doi.org/10.1007/BF00140203
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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