Immunostimulating components from the root of Angelica gigas Nakai = 참당귀(Angelica gigas Nakai) 뿌리의 면역증강활성 성분

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Title
Immunostimulating components from the root of Angelica gigas Nakai = 참당귀(Angelica gigas Nakai) 뿌리의 면역증강활성 성분
Author(s)
Kyung Seop Ahn; Woong Seop Sim; Hwan Mook Kim; Sang Bae Han; Ik Hwan Kim
Bibliographic Citation
Korean Journal of Pharmacognosy, vol. 27, no. 3, pp. 254-261
Publication Year
1996
Abstract
A potent immune-stimulating activity was detected from the watersoluble and ethanol-precipitated crude extract (AG-1) of the root of Angelica gigas Nakai. The crude extract was fractionated into two fractions, an acidic AG-2 and a neutral AG-3 fraction by DEAE-cellulose adsorption. The two fractions contained polysaccharides of which M.W. were 10 Kdal and >2,000 Kdal respectively, proteins, and vanous inorganic components. The immunostimulating activities of two fractions were not reduced by proteinase K, acid or alkali treatment. The polysaccharides obtained from the root of A. gigas were mainly composed of arabinose, galactose, and galacturonic acid. These results indicated that immune-stimulating components of the root of A. gigas was a kind of pectic polysaccharides or arabinogalactans.
Keyword
pectic polysaccharideAngelica gigasarabinogalactanimmuno-stimulating activitymixed leukocyte reaction
ISSN
0253-3073
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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