Selective suppression of In vitro T-dependent humoral immunity by synthetic food additive antioxidants

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Title
Selective suppression of In vitro T-dependent humoral immunity by synthetic food additive antioxidants
Author(s)
Hwan Mook Kim; Sang Bae Han; Woo Ick Chang; Byung Hwa Hyun; Goo Taeg Oh; Chang Joon Ahn; Young Nam Cha
Bibliographic Citation
Journal of Toxicological Sciences, vol. 21, pp. 41-45
Publication Year
1996
Abstract
Effect of antioxidants on humoral immune responses, such as butylated hydroxytoluene (BHT), n-propyl gallate (PG) and dimethyl sulfoxide (DMSO) is suppression in in vitro antibody production. These antioxidants all inhibited T-dependent B cell response, not T-independent and polyclonal B cell response. These data suggest that antioxidants suppress humoral immunity by suppression of regulation of T cells or action of macrophages on B cells, not by direct suppression of B cells. The other possible explanation for antioxidant action is the lack of T-b cell contact required for the triggering of the B cell response with T-dependent antigens.
Keyword
BHTDMSOPGPrimary antibody responses
ISSN
0388-1350
Publisher
Japanese Soc Toxicological Sciences
DOI
http://dx.doi.org/10.2131/jts.21.41
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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