Antifungal effect of melittin-hybrid synthetic peptides for Fusarium oxysporum = Melittin-hybrid 합성 펩타이드가 Fusarium oxysporum의 성장에 미치는 저해효과

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dc.contributor.authorDong Gun Lee-
dc.contributor.authorSong Yub Shin-
dc.contributor.authorSung Gu Lee-
dc.contributor.authorMyung Kyu Lee-
dc.contributor.authorKyung Soo Hahm-
dc.date.accessioned2017-04-19T08:45:40Z-
dc.date.available2017-04-19T08:45:40Z-
dc.date.issued1996-
dc.identifier.issn0257-2389-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/3848-
dc.description.abstractMelittin (ME) from honey-bee venom has a broad range of strong antimicrobial activity, but it has hemolytic activity against eukaryotic cells. In order to design peptides with powerful antifungal activity without cytotoxic property of ME and understand structure-antifungal activity relationships, the hybrid peptides derived from the sequences of ME and cecropin A (CA) or magainin 2 (MA), MA(10-17)ME(1-12) and CA(1-8)ME(1-12), were synthesized by solid phase method. MA(10-17)ME(1-12) showed potent antifungal activity comparable to ME against Fusarium oxysporum with no hemolytic activity against human red blood cells. The hybrid peptides showed strong inhibition of (1,3)-β-D-glucan synthase. This result indicates that the antifungal activity of the hybrid peptides against Fusarium oxysporum is attributed to the inhibition of cell wall synthesis. The results therefore showed a successful design of a peptide having antifungal activity without hemolytic property.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleAntifungal effect of melittin-hybrid synthetic peptides for Fusarium oxysporum = Melittin-hybrid 합성 펩타이드가 Fusarium oxysporum의 성장에 미치는 저해효과-
dc.title.alternativeAntifungal effect of melittin-hybrid synthetic peptides for Fusarium oxysporum-
dc.typeArticle-
dc.citation.titleKorean Journal of (Applied) Microbiology & Biotechnology-
dc.citation.number5-
dc.citation.endPage533-
dc.citation.startPage529-
dc.citation.volume24-
dc.contributor.affiliatedAuthorDong Gun Lee-
dc.contributor.affiliatedAuthorSong Yub Shin-
dc.contributor.affiliatedAuthorSung Gu Lee-
dc.contributor.affiliatedAuthorMyung Kyu Lee-
dc.contributor.affiliatedAuthorKyung Soo Hahm-
dc.contributor.alternativeName이동건-
dc.contributor.alternativeName신송엽-
dc.contributor.alternativeName이성구-
dc.contributor.alternativeName이명규-
dc.contributor.alternativeName함경수-
dc.identifier.bibliographicCitationKorean Journal of (Applied) Microbiology & Biotechnology, vol. 24, no. 5, pp. 529-533-
dc.subject.keywordβ-1.3 glucan synthase-
dc.subject.keywordAntifungal activity-
dc.subject.keywordHybrid peptide-
dc.subject.keywordMelittin-
dc.subject.localβ-1.3 glucan synthase-
dc.subject.localβ-1,3-glucan synthase-
dc.subject.localAntifungal activity-
dc.subject.localAnti-fungal activity-
dc.subject.localantifungal activity-
dc.subject.localHybrid peptide-
dc.subject.localHybrid peptides-
dc.subject.localhybrid peptide-
dc.subject.localMelittin-
dc.subject.localmelittin-
dc.description.journalClassN-
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