A specific association of ERK3 with B-raf in rat hippocampus

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Title
A specific association of ERK3 with B-raf in rat hippocampus
Author(s)
Seung Ho Kim; Yun Chung Yang
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 229, pp. 577-581
Publication Year
1996
Abstract
The possible formation of a stable complex between extracellular signal-regulated kinases (ERKs) and Raf protein kinases was investigated in an attempt to understand the molecular mechanism by which Raf protein kinases were differentially regulated in response to the various stimuli, leading to the activation of ERKs in rat hippocampus. ERK3 was found to coelute with B-Raf, but not c-Raf1, after fractionation of rat hippocampal lysates by QMA anionic exchange chromatography. ERK3 was released into soluble supernatant fraction from the B-Raf, but not c-Raf1, immunoprecipitate, after incubation with ATP. These results, taken together, suggest the specific association of ERK3 with B-Raf in rat hippocampus.
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1006/bbrc.1996.1846
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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