Inhibition of histamine synthesis by glycyrrhetinic acid in mast cells cocultured with Swiss 3T3 fibroblasts

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dc.contributor.authorYoung-Mi Lee-
dc.contributor.authorS Hirota-
dc.contributor.authorT Jippo-Kanemoto-
dc.contributor.authorHyung-Ryong Kim-
dc.contributor.authorTae-Yong Shin-
dc.contributor.authorYoung Il Yeom-
dc.contributor.authorKyung Kwang Lee-
dc.contributor.authorY Kitamura-
dc.contributor.authorS Nomura-
dc.contributor.authorHyung-Min Kim-
dc.date.accessioned2017-04-19T08:53:40Z-
dc.date.available2017-04-19T08:53:40Z-
dc.date.issued1996-
dc.identifier.issn1018-2438-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/3874-
dc.description.abstractThe effect of glycyrrhetinic acid (18-O-β-glycyrrhetinic acid, GA) on histamine metabolism was investigated in cultured mast cells (CMCs) cocultured with Swiss 3T3 fibroblasts. GA strongly inhibited histamine synthesis in the cocultured CMCs. Since 50 μM GA inhibited about 80% of histidine decarboxylase (HDC) activity, the inhibitory activity of GA for histamine synthesis was considered to be derived from the inhibition of HDC activity. The number of berberine-sulfate-positive cells also decreased in the presence of GA, which indicated that maturation of CMCs was inhibited by GA. Futhermore, we examined the effect of GA on the mRNA expression of novel protein kinase C δ (nPKCδ), a major isoform of CMCs, by Northern blot analysis. The expression of nPKCδ mRNA in the presence of GA was significantly lower than in the absence of GA. These results suggest the possibility that the inhibition of histamine synthesis by GA is regulated by nPKCδ.-
dc.publisherKarger-
dc.titleInhibition of histamine synthesis by glycyrrhetinic acid in mast cells cocultured with Swiss 3T3 fibroblasts-
dc.title.alternativeInhibition of histamine synthesis by glycyrrhetinic acid in mast cells cocultured with Swiss 3T3 fibroblasts-
dc.typeArticle-
dc.citation.titleInternational Archives of Allergy and Immunology-
dc.citation.number0-
dc.citation.endPage277-
dc.citation.startPage272-
dc.citation.volume110-
dc.contributor.affiliatedAuthorYoung Il Yeom-
dc.contributor.affiliatedAuthorKyung Kwang Lee-
dc.contributor.alternativeName이영미-
dc.contributor.alternativeNameHirota-
dc.contributor.alternativeNameJippo-Kanemoto-
dc.contributor.alternativeName김형룡-
dc.contributor.alternativeName신태웅-
dc.contributor.alternativeName염영일-
dc.contributor.alternativeName이경광-
dc.contributor.alternativeNameKitamura-
dc.contributor.alternativeNameNomura-
dc.contributor.alternativeName김형민-
dc.identifier.bibliographicCitationInternational Archives of Allergy and Immunology, vol. 110, pp. 272-277-
dc.identifier.doi10.1159/000237298-
dc.subject.keywordGlycyrrhetinic acid-
dc.subject.keywordHistidine decarboxylase-
dc.subject.keywordProtein kinase C-
dc.subject.keywordStem cell factor-
dc.subject.localGlycyrrhetinic acid-
dc.subject.localHistidine decarboxylase-
dc.subject.localProtein kinase C-
dc.subject.localprotein kinase C-
dc.subject.localprotein kinase c-
dc.subject.localStem cell factor-
dc.description.journalClassY-
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Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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