Role of HLA class II alleles in Korean patients with IDDM

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Title
Role of HLA class II alleles in Korean patients with IDDM
Author(s)
H C Lee; H Ikegami; T Fugisana; T Ogihara; S W Park; Y S Chung; J O Park; E J Lee; S K Lim; K R Kim; K B Huh; Yong Sung Kim; Dae Sil Lee; D H Kim
Bibliographic Citation
Diabetes Research and Clinical Practice, vol. 31, pp. 9-15
Publication Year
1996
Abstract
MHC associations with IDDM in the Korean population were studied to investigate genetic susceptibility to this disorder. The frequencies of HLA-DR3, -DR4 and -DR9 were significantly higher in diabetic patients. However, the frequency of DR2 was significantly decreased in diabetic patients. DQA1*0301 and DQA1*0501 were positively and DQA1*0102 and DQA1*0201 negatively associated with IDDM. DQB1*0301 and DQB1*0601 were negatively associated with IDDM. Heterodimers DQA1*0301-DQB1*0201, DQA1*0501-DQB1*0201 and DQA1*0501-DQB1*0302 were positively associated and DQA1*0102-DQB1*0601 negatively associated with IDDM. The frequencies of DR3-DQB1*0301-DQB1*0201 and -DQA1*0501-DQB1*0201 were significantly higher in diabetic patients. The frequencies of DR4-DQA1*0301 DQB1*0201 and DR9-DQA1*0301-DQB1*0303 were significantly higher in diabetic patients. The presence of non-aspartic acid at position 57 of the DQβ-chain was not associated with susceptibility to IDDM. However, the frequency of Arg 52 homozygotes was significantly higher in diabetic patients. These results suggest a role of the MHC molecule and also suggest racial differences in susceptibility to IDDM even within the Asian populations.
Keyword
HLAHuman leukocyte antigenIDDMInsulin-dependent diabetes mellitusPCRPolymerase chain reaction
ISSN
0168-8227
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/0168-8227(96)01200-4
Type
Article
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1. Journal Articles > Journal Articles
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