Benzastatins E, F, and G : new indoline alkaloids with neuronal cell protecting activity from Streptomyces nitrosporeus

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Title
Benzastatins E, F, and G : new indoline alkaloids with neuronal cell protecting activity from Streptomyces nitrosporeus
Author(s)
Won Gon KimJong Pyung Kim; H Koshino; K Shin-Ya; H Seto; Ick Dong Yoo
Bibliographic Citation
Tetrahedron, vol. 53, no. 12, pp. 4309-4316
Publication Year
1997
Abstract
Three new indoline alkaloids, benzastatins E (5), F (6), and G (7), were isolated from the culture broth of Streptomyces nitrosporeus 30643 as neuronal cell protecting substances. Their structures were elucidated on the basis of spectral data, 5, 6, and 7 suppressed glutamate toxicity in N18-RE-105 cells with EC50 values of 1.7, 3.6, and 12.2 μM, respectively.
ISSN
0040-4020
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0040-4020(97)00157-9
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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