New indole derivatives with free radical scavenging activity from Agrocybe cylindracea

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Title
New indole derivatives with free radical scavenging activity from Agrocybe cylindracea
Author(s)
Won Gon Kim; In Kyoung Lee; Jong Pyung KimIn Ja Ryoo; H Koshino; Ick Dong Yoo
Bibliographic Citation
Journal of Natural Products, vol. 60, no. 7, pp. 721-723
Publication Year
1997
Abstract
Two new indole derivatives were isolated as free radical scavengers from the MeOH extract of Agrocybe cylindracea. The structures of these compounds were determined to be 6-hydroxy-1H-indole-3-carboxaldehyde (1) and 6-hydroxy- 1H-indole-3-acetamide (2) on the basis of spectroscopic studies. Compounds 1 and 2 inhibited lipid peroxidation in rat liver microsomes, with IC50 values of 4.1 and 3.9 μg/mL, respectively.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np970150w
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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