Bat organoid platform: revolutionizing zoonotic virus research and pandemic preparedness

Abstract

Beyond infectious disease modeling, bat organoids offer a promising platform for aging research. Bats exhibit exceptional longevity and healthy aging, featuring robust cancer resistance, ef？cient DNA repair, and unique immune regulation. These organoid systems could elucidate the molecular mechanisms underlying such adaptations, potentially informing healthy human aging strategies. Ultimately, continued technological innovation, including the development of a digital bat organoid platform integrated with advanced modeling and computational meth- odologies, may facilitate a more harmonious balance between human society and natural ecosystems, supporting proactive management of zoonotic threats and preserving biodiversity.