New diphenazines with neuronal cell protecting activity, phenazostatins A and B, produced by Streptomyces sp.

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Title
New diphenazines with neuronal cell protecting activity, phenazostatins A and B, produced by Streptomyces sp.
Author(s)
Won Gon KimIn Ja Ryoo; Bong Sik Yun; K Shin-Ya; H Seto; Ick Dong Yoo
Bibliographic Citation
Journal of Antibiotics, vol. 50, no. 9, pp. 715-721
Publication Year
1997
Abstract
Phenazostatins A and B, new diphenazine compounds, were isolated from the culture broth of Streptomyces sp. 833 as new neuronal cell protecting substances which also showed free radical scavenging activity. In the cell assay, phenazostatins A and B inhibited glutamate toxicity in N18-RE-105 cells with EC50 values of 0.34 and 0.33 μM, respectively.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.7164/antibiotics.50.715
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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