Open Access@KRIBBDivision of Research on National ChallengesPlant Systems Engineering Research1. Journal Articles
Cystatin-mediated enhancement of human epidermal growth factor bioproduction in plants
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- Title
- Cystatin-mediated enhancement of human epidermal growth factor bioproduction in plants
- Author(s)
- Hyun Ji Park; Seung Hee Jo; Hyeonseo Park; Haemyeong Jung; Suk Yoon Kwon; Hyun-Soon Kim; Sang Jick Kim; Hye Sun Cho
- Bibliographic Citation
- Journal of Integrative Plant Biology, vol. 67, no. 9, pp. 2256-2258
- Publication Year
- 2025
- Abstract
- Human epidermal growth factor (EGF) fused with the protease inhibitor SlCYS8 and produced in plants showed enhanced stability, yield, and biological activity. This fusion strategy reduced degradation and outperformed commercial EGF in cell-based assays, demonstrating a promising approach for producing stable, functional proteins in plant systems for pharmaceutical applications.
- ISSN
- 1672-9072
- Publisher
- Wiley
- Full Text Link
- http://dx.doi.org/10.1111/jipb.13936
- Type
- Article
- Appears in Collections:
- Division of Research on National Challenges > Plant Systems Engineering Research > 1. Journal Articles
Synthetic Biology and Bioengineering Research Institute > Synthetic Biology Research Center > 1. Journal Articles
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