Cloning and characterization of cDNAs coding for heavy and light chains of a monoclonal antibody specific for the S antigen of hepatitis B virus

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Title
Cloning and characterization of cDNAs coding for heavy and light chains of a monoclonal antibody specific for the S antigen of hepatitis B virus
Author(s)
Chun Jeih Ryu; Byung Rae Jin; Hong Keung Chung; Moon Hi Han; Hyo Jeong Hong
Bibliographic Citation
Gene, vol. 144, pp. 313-314
Publication Year
1994
Abstract
The nucleotide (nt) sequences encoding the variable regions of the heavy and light chains of a murine monoclonal antibody (mAb) have been determined. The mAb recognizes a disulfide-bond-dependent conformational epitope on the hepatitis B virus surface antigen. The sequence analyses revealed that the variable regions of the heavy and light chains are members of mouse heavy- chain subgroup II(A) and κ light-chain subgroup III, respectively.
Keyword
HBVimmunoglobulinmousepolymerase chain reactionRecombinant DNA
ISSN
0378-1119
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/0378-1119(94)90398-0
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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