DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tae-Ho Jung | - |
dc.contributor.author | J. C. Kim | - |
dc.contributor.author | M.K. Kim | - |
dc.contributor.author | S. C. Choi | - |
dc.contributor.author | S. L. Kim | - |
dc.contributor.author | J. M. Chung | - |
dc.contributor.author | I. S. Lee | - |
dc.contributor.author | Seung Ho Kim | - |
dc.contributor.author | Kyung Soo Hahm | - |
dc.contributor.author | I. P. Lee | - |
dc.date.accessioned | 2017-04-19T08:54:23Z | - |
dc.date.available | 2017-04-19T08:54:23Z | - |
dc.date.issued | 1995 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/4006 | - |
dc.description.abstract | The present study was undertaken to identify potential phytotherapeutic agents among the aqueous extracts of 151 herbal medicinal plants of Korea. Extracts were assayed for (1) binding potency to hepatitis B-virus surface antigen (HBsAg), and (2) inhibition of serum hepatitis B-virus DNA polymerase activity. of the 151 aqueous plant extracts tested 33 demonstrated a positive precipitation reaction with HBsAg+ serum, and 15 of these specifically bound HBsAg in serum as well as recombinant HBsAg (Hepavax). Nine extracts competitively inhibited >80% of anti-HBsAg antibody binding to Hepavax® HBsAg. Furthermore, nine of these 15 plant extracts also exhibited greater than 25%-50% inhibition of hepatitis B-virus DNA polymerase activity, and also significantly stimulated production of the potent cytokine, tumour necrosis factor (TNF). None of the extract concentrations used altered liver function parameters of normal rats. | - |
dc.publisher | Wiley | - |
dc.title | Investigation of Korean plant extracts for potential phytotherapeutic agents against B-virus hepatitis | - |
dc.title.alternative | Investigation of Korean plant extracts for potential phytotherapeutic agents against B-virus hepatitis | - |
dc.type | Article | - |
dc.citation.title | Phytotherapy Research | - |
dc.citation.number | 6 | - |
dc.citation.endPage | 434 | - |
dc.citation.startPage | 429 | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Tae-Ho Jung | - |
dc.contributor.affiliatedAuthor | Seung Ho Kim | - |
dc.contributor.affiliatedAuthor | Kyung Soo Hahm | - |
dc.contributor.alternativeName | 정태호 | - |
dc.contributor.alternativeName | J.C.Kim | - |
dc.contributor.alternativeName | M.K.Kim | - |
dc.contributor.alternativeName | S.C.Choi | - |
dc.contributor.alternativeName | S.L.Kim | - |
dc.contributor.alternativeName | J.M.Chung | - |
dc.contributor.alternativeName | I.S.Lee | - |
dc.contributor.alternativeName | 김승호 | - |
dc.contributor.alternativeName | 함경수 | - |
dc.contributor.alternativeName | I.P.Lee | - |
dc.identifier.bibliographicCitation | Phytotherapy Research, vol. 9, no. 6, pp. 429-434 | - |
dc.identifier.doi | 10.1002/ptr.2650090609 | - |
dc.subject.keyword | HBV DNA polymerase | - |
dc.subject.keyword | Human hepatitis B-virus (HBV) | - |
dc.subject.keyword | Korean medicinal plants | - |
dc.subject.keyword | Tumour necrosis factor | - |
dc.subject.local | HBV DNA polymerase | - |
dc.subject.local | Human hepatitis B-virus (HBV) | - |
dc.subject.local | Korean medicinal plants | - |
dc.subject.local | Tumour necrosis factor | - |
dc.subject.local | tumour necrosis factor | - |
dc.description.journalClass | Y | - |
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