Investigation of Korean plant extracts for potential phytotherapeutic agents against B-virus hepatitis

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dc.contributor.authorTae-Ho Jung-
dc.contributor.authorJ. C. Kim-
dc.contributor.authorM.K. Kim-
dc.contributor.authorS. C. Choi-
dc.contributor.authorS. L. Kim-
dc.contributor.authorJ. M. Chung-
dc.contributor.authorI. S. Lee-
dc.contributor.authorSeung Ho Kim-
dc.contributor.authorKyung Soo Hahm-
dc.contributor.authorI. P. Lee-
dc.date.accessioned2017-04-19T08:54:23Z-
dc.date.available2017-04-19T08:54:23Z-
dc.date.issued1995-
dc.identifier.issn0951-418X-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4006-
dc.description.abstractThe present study was undertaken to identify potential phytotherapeutic agents among the aqueous extracts of 151 herbal medicinal plants of Korea. Extracts were assayed for (1) binding potency to hepatitis B-virus surface antigen (HBsAg), and (2) inhibition of serum hepatitis B-virus DNA polymerase activity. of the 151 aqueous plant extracts tested 33 demonstrated a positive precipitation reaction with HBsAg+ serum, and 15 of these specifically bound HBsAg in serum as well as recombinant HBsAg (Hepavax). Nine extracts competitively inhibited >80% of anti-HBsAg antibody binding to Hepavax® HBsAg. Furthermore, nine of these 15 plant extracts also exhibited greater than 25%-50% inhibition of hepatitis B-virus DNA polymerase activity, and also significantly stimulated production of the potent cytokine, tumour necrosis factor (TNF). None of the extract concentrations used altered liver function parameters of normal rats.-
dc.publisherWiley-
dc.titleInvestigation of Korean plant extracts for potential phytotherapeutic agents against B-virus hepatitis-
dc.title.alternativeInvestigation of Korean plant extracts for potential phytotherapeutic agents against B-virus hepatitis-
dc.typeArticle-
dc.citation.titlePhytotherapy Research-
dc.citation.number6-
dc.citation.endPage434-
dc.citation.startPage429-
dc.citation.volume9-
dc.contributor.affiliatedAuthorTae-Ho Jung-
dc.contributor.affiliatedAuthorSeung Ho Kim-
dc.contributor.affiliatedAuthorKyung Soo Hahm-
dc.contributor.alternativeName정태호-
dc.contributor.alternativeNameJ.C.Kim-
dc.contributor.alternativeNameM.K.Kim-
dc.contributor.alternativeNameS.C.Choi-
dc.contributor.alternativeNameS.L.Kim-
dc.contributor.alternativeNameJ.M.Chung-
dc.contributor.alternativeNameI.S.Lee-
dc.contributor.alternativeName김승호-
dc.contributor.alternativeName함경수-
dc.contributor.alternativeNameI.P.Lee-
dc.identifier.bibliographicCitationPhytotherapy Research, vol. 9, no. 6, pp. 429-434-
dc.identifier.doi10.1002/ptr.2650090609-
dc.subject.keywordHBV DNA polymerase-
dc.subject.keywordHuman hepatitis B-virus (HBV)-
dc.subject.keywordKorean medicinal plants-
dc.subject.keywordTumour necrosis factor-
dc.subject.localHBV DNA polymerase-
dc.subject.localHuman hepatitis B-virus (HBV)-
dc.subject.localKorean medicinal plants-
dc.subject.localTumour necrosis factor-
dc.subject.localtumour necrosis factor-
dc.description.journalClassY-
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