Genomic aberrations in human hepatoblastomas detected by 2-dimensional gel analysis

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Title
Genomic aberrations in human hepatoblastomas detected by 2-dimensional gel analysis
Author(s)
Hisaki Nagai; Hiroaki Tsumura; Mathurose Ponglikitmongkol; Yong Sung Kim; Kenichi Matsubara
Bibliographic Citation
Cancer Research, vol. 55, no. 20, pp. 4549-4551
Publication Year
1995
Abstract
Hepatoblastoma is a frequent embryonic tumor found in children. The mechanism of its formation and development remain unknown. We analyzed genomic DNA aberrations associated with three hepatoblastomas by means of restriction landmark genomic scanning (I. Hatada et al., Proc. Natl. Acad. Sci. USA, 88:9523-9527, 1991). About 2000 Not1 restriction landmarks were monitored in each of the hepatoblastomas, which revealed that the intensity of eight spots decreased in the tumor genome, suggesting allelic loss. Three of these spots were identical to those that decreased in human hepatocellular carcinomas. These results suggested that common, early events are involved in the genesis of the two types of liver tumor.
Keyword
humanhuman tissuetwo dimensional gel electrophoresisElectrophoresis, Gel, Two-DimensionalHuman
ISSN
0008-5472
Publisher
Amer Assoc Cancer Research
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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