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- 성장호르몬결핍성 환아에서 혈중 1형 인슐린양 성장인자(IGF-I)와 약물자극으로 분비된 성장호르몬과의 연관성
- Pil-Soo Oh; Kee-Jong Kim; Young-E Yoo; In-June Sul; Jae Hoon Shin; Young Ik Lee
- Bibliographic Citation
- Journal of Korean Pediatric Society, vol. 38, no. 10, pp. 1394-1403
- Publication Year
- Purpose : This study aimed to determine the best cutoff line for insulin-like growth factor (IGF)-I and insulin-like growth
factor binding protein (IGFBP)-3 to discriminate between growth hormone de ficiency (GHD) patients and the control group.
Methods : Two hundred thirty subjects with normal controls (129 boys and 101 girls, aged 7-15 years), 14 patients with
complete GHD (12 boys and 2 girls), and 17 patients with partial GHD (9 boys and 8 girls) were studied. IGF-I serum concentrations were measured by radioimmunoassay (RI), and IGFBP-3 concentrations were measured by immunoradiometric
Results : The receiver operating characteristic (ROC) plot analysis showed that the best IGF-I and IGFBP-3 cutoff line was
at -1 standard deviation (SD). By comparing IGF-I serum levels of GHD children within 1 SD of normal control, we determined
the sensitivity (S) (87.5-100%) and specificity (Sp) (80-84.6%) according to the age group. For IGFBP-3, we determined the
following values: S (58.7-85.7%) and Sp (79.2-85.5%). Eleven of 14 patients with complete GHD (78.5%) and 16 of 17
patients with partial GHD (94.1%) had IGF-I concentrations equal to or below -1 SD of the control group mean. Ten of 12
complete GHD children (83.3%) and 13 of 17 partial GHD children (76.5%) had IGFBP-3 concentrations equal or below -1
SD of the control group mean.
Conclusion : We conclude that the measurement of IGF-I and IGFBP-3 concentrations might provide essential supplementary
data in the diagnostic evaluation of patients with GHD. Our results support the need to use cutoff lines based on below -1
SD of the control.
- Insulin-like growth factor-IInsulin-like growth factor binding protein-3Growth hormone de ficiency
- Korea Soc-Assoc-Inst
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- 1. Journal Articles > Journal Articles
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