Anti-inflammatory effects of Stephania tetrandra S. moore on interleukin-6 production and experimental inflammatory disease models

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Title
Anti-inflammatory effects of Stephania tetrandra S. moore on interleukin-6 production and experimental inflammatory disease models
Author(s)
Hyung Sik Kang; Young Ho Kim; C S Lee; Jung Joon Lee; In Pyo Choi; Kwang Ho Pyun
Bibliographic Citation
Mediators of Inflammation, vol. 5, pp. 280-291
Publication Year
1996
Abstract
Deregulation of interleukin-6 (IL-6) expression caused the synthesis and release of many inflammatory mediators. It is involved in chronic inflammation, autoimmune diseases, and malignancy. Stephania tetrandra S. Moore is a Chinese medicinal herb which has been used traditionally as a remedy for neuralgia and arthritis in China. To investigate the anti-inflammatory effects of S. tetrandra S. Moore in vitro and in vivo, its effects on the production of IL-6 and inflammatory mediators were analysed. When human monocytes/macrophages stimulated with silica were treated with 0.1-10 μg/ml S. tetranda S. Moore, the production of IL-6 was inhibited up to 50%. At these concentrations, it had no cytotoxicity effect on these cells. It also suppressed the production of IL-6 by alveolar macrophages stimulated with silica. In addition, it inhibited the release of superoxide anion and hydrogen peroxide from human monocytes/macrophages. To assess the anti-fibrosis effects of S. tetrandra S. Moore, its effects on in vivo experimental inflammatory models were evaluated. In the experimental silicosis model, IL-6 activities in the sera and in the culture supernatants of pulmonary fibroblasts were also inhibited by it. In vitro and in vivo treatment of S. tetrandra S. Moore reduced collagen production by rat lung fibroblasts and lung tissue. Also, S. tetrandra S. Moore reduced the levels of serum GOT and GPT in the rat cirrhosis model induced by CCl4, and it was effective in reducing hepatic fibrosis and nodular formation. Taken together, these data indicate that it has a potent anti-inflammatory and antifibrosis effect by reducing IL-6 production.
Keyword
anti-fibrosisanti-inflammationIL-6 productionStephania tetrandra
ISSN
0962-9351
Publisher
Hindawi Ltd
DOI
http://dx.doi.org/10.1155/S0962935196000415
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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