Complete sequence of the UPP gene encoding uracil phosphoribosyltransferase from Mycobacterium bovis BCG

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Title
Complete sequence of the UPP gene encoding uracil phosphoribosyltransferase from Mycobacterium bovis BCG
Author(s)
Jin Koo Kim; Jeong Hyun Kim; Seung-Hwan Lee; Young Kang; Jong-Seok Lim; Hee Gu Lee; Sang Jae Kim; Gill Han Bai; Young Kil Park; Sang-Hyun Cho; Sang Won Kang; Yu Sam Kim; In Seong Choe; Tai Wha Chung; Sue Nie Park; Seung Ho Kim; Jong Seog Ahn; Yong Kyung Choe
Bibliographic Citation
Biochemistry and Molecular Biology International, vol. 41, no. 6, pp. 1117-1124
Publication Year
1997
Abstract
The nucleotide sequence of a 799 bp fragment of Mycobacterium bovis BCG containing the putative upp gene that encodes a uracil phosphoribosyltransferase (UPRTase [EC 2.4.2.9]) has been determined. The upp gene of BCG has an open reading frame (ORF) of 621 bp (207 amino acids) starting with GTG (position 112) and ending with TGA (position 733), and its molecular mass was calculated to be 21,864 Da. Comparative analyses of the deduced amino acid sequence of BCG UPRTase with the UPRTase of six bacterial genera revealed that 24% (50/211) of die residues are perfectly conserved and 32% (67/211) of the residues are well conserved.
Keyword
BCGuppUracil phosphoribosyltraltsferase
ISSN
1039-9712
Publisher
Wiley
DOI
http://dx.doi.org/10.1080/15216549700202201
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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