Topical anti-inflammatory activity of dianemycin isolated from Streptomyces sp. MT 2705-4

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Title
Topical anti-inflammatory activity of dianemycin isolated from Streptomyces sp. MT 2705-4
Author(s)
Song Jin Lee; Hyun Pyo Kim; Byoung Keun Park; Soon Cheol Ahn; Hyun Sun Lee; Jong Seog Ahn
Bibliographic Citation
Archives of Pharmacal Research, vol. 20, no. 4, pp. 372-374
Publication Year
1997
Abstract
In order to develop new anti-inflammatory agents having different action mechanisms compared with nonsteroidal and steroidal anti-inflammatory drugs, the culture broths of various actinomycetes isolated from soil were screened using an in vivo mouse ear edma assay and one strain (Streptomyces sp. MT 2705-4: KCTC 8651P) was selected. Activity-guided purification led to the isolation of a polyether compound, dianemycin. Topically, dianemycin showed a potent anti-inflammatory activity in mouse ear edema induced by croton-oil or arachidonic acid. ED50 value of dianemycin was found to be 0.8 mg/ear compared to 0.4 mg/ear of prednisolone in croton-oil ear edema. However, dianemycin did not show the inhibitory activity in UV-erythema and delayed hypersensitivity reaction. These results indicate that dianemycin is a potential topical anti-inflammatory agent.
Keyword
Anti-inflammatory activityDelayed hypersensitivityDianemycinEar edemaStreptomycesTopicalUV-erythema
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02976203
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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