Acyl-CoA : cholesterol acyltransferase inhibitors from Magnolia obovata

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Title
Acyl-CoA : cholesterol acyltransferase inhibitors from Magnolia obovata
Author(s)
Byoung-Mog Kwon; Mi Kyung Kim; Seung Ho Lee; Jeong-Ah Kim; Ihn-Rhan Lee; Young Kook Kim; Song Hae Bok
Bibliographic Citation
Planta Medica, vol. 63, no. 6, pp. 550-551
Publication Year
1997
Abstract
In the course of a search for acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors from natural sources, new types of ACAT inhibitors were isolated from the extract of Magnolia obovata leaves, and identified as obovatol, honokiol, and magnolol. The active compounds inhibit rat liver ACAT with IC50 values of 42, 71, and 86 μM, respectively.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2006-957762
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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