Polymorphic sequence of Korean native goat lactoferrin exhibiting greater antibacterial activity

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Title
Polymorphic sequence of Korean native goat lactoferrin exhibiting greater antibacterial activity
Author(s)
Tae Hoon Lee; K Shimazaki; S L Yu; Myung Soo Nam; Sun Jung Kim; Kyung Kwang Lee; Dae Yeul Yu
Bibliographic Citation
Animal Genetics, vol. 28, pp. 367-369
Publication Year
1997
Abstract
Lactoferrin, which exhibits antibacterial activity to protect infants from infectious disease, is a major component of colostrum and milk. Lactoferrin was purified from the colostrum of Korean Native goat, and the cDNA from the mammary gland mRNA of the animal was cloned and sequenced. The nucleotide sequence of the lactoferrin gene of Korean Native goat was found to differ in 15 sites from that of the goat lactoferrin gene reported earlier. This difference in nucleotide sequence resulted in six amino acid substitutions: five in the N-lobe and one in the C-lobe. The antibacterial activity of Korean Native goat lactoferrin was found to be greater than that of Sannen goat lactoferrin.
Keyword
antibacterial activityKorean Native goatlactoferrin polymorphism
ISSN
0268-9146
Publisher
Wiley
DOI
http://dx.doi.org/10.1111/j.1365-2052.1997.00154.x
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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