MR566A and MR566B, new melanin synthesis inhibitors produced by Trichoderma harzianum I. : taxonomy, fermentation, isolation and biological activities

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Title
MR566A and MR566B, new melanin synthesis inhibitors produced by Trichoderma harzianum I. : taxonomy, fermentation, isolation and biological activities
Author(s)
Choong Hwan Lee; Myung Chul Chung; Ho Jae Lee; Kyung Sook Bae; Yung Hee Kho
Bibliographic Citation
Journal of Antibiotics, vol. 50, no. 6, pp. 469-473
Publication Year
1997
Abstract
New melanin synthesis inhibitors (MR566A and B) and six related known isocyanocyclopentenes were isolated from the fermentation broth of Trichoderma harzianum. The IC50 values of MR566A and B against mushroom tyrosinase were 1.72 and 47 μM, respectively. They inhibited melanin biosynthesis in B16 melanoma cells with MIC values of 0.1 and 2.2 μM, respectively. Also isolated from the same culture extract of T. harzianum was a new oxazole (MR93B), which showed no inhibitory activity against mushroom tyrosinase at a concentration of 1,000 μg/ml.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.7164/antibiotics.50.469
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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