MR566A and MR566B, new melanin synthesis inhibitors produced by Trichoderma harzianum II. : physico-chemical properties and structural elucidation

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Title
MR566A and MR566B, new melanin synthesis inhibitors produced by Trichoderma harzianum II. : physico-chemical properties and structural elucidation
Author(s)
Choong Hwan Lee; Hiroyuki Koshino; Myung Chul Chung; Ho Jae Lee; Jong Ki Hong; Jong Shin Yoo; Yung Hee Kho
Bibliographic Citation
Journal of Antibiotics, vol. 50, no. 6, pp. 474-478
Publication Year
1997
Abstract
New melanin synthesis inhibitors (MR566A and B) and six related known isocyanocyclopentenes were isolated from the fermentation broth of Trichoderma harzianum, and their structures were elucidated by spectroscopic methods. The structures of novel isocyanides, MR566A (1) and B (2), were elucidated as 1-(3-chloro-1,2-dihydroxy-4-isocyano-4-cyclopenten-1-yl)ethanol, 1-(1,2,3-trihydroxy-3-isocyano-4-cyclopenten-1-yl)ethanol, respectively. The structure of novel oxazole, MR93B (9), was elucidated as 4-[(1Z)-3-hydroxy-2-hydroxymethyl-1-propen-1-yl]oxazole.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.7164/antibiotics.50.474
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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