Enantioselective N-acetylation of 3-amino-3-phenylpropionic acid by cell-free extracts of Streptomyces neyagawaensis
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- Title
- Enantioselective N-acetylation of 3-amino-3-phenylpropionic acid by cell-free extracts of Streptomyces neyagawaensis
- Author(s)
- Myung Chul Chung; Ho Jae Lee; Choong Hwan Lee; Hyo Kon Chun; Yung Hee Kho
- Bibliographic Citation
- Journal of Microbiology and Biotechnology, vol. 7, no. 5, pp. 329-332
- Publication Year
- 1997
- Abstract
- Cell-free extracts of Streptomyces neyagawaensis SL-387 grown on a chemically defined medium supplemented with DL-3-amino-3-phenylpropionic acid (APP) produced N-acetyl-APP (Ac-APP) in the presence of APP and acetyl coenzyme A. The APP obtained by acid hydrolysis of the Ac-APP was D-configuration: [α]D+6.5° (H2O) at 20°C, optical purity 92% enantiomeric excesses (ee). These results suggest that an N-acetyltransferase exists in the cell-free extract as a novel enzyme with specificity for D-APP.
- ISSN
- 1017-7825
- Publisher
- Korea Soc-Assoc-Inst
- Type
- Article
- Appears in Collections:
- Division of Bio Technology Innovation > SME Support Center > 1. Journal Articles
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