Biosynthesis of peptide inhibitor MR-387 by Streptomyces neyagawaensis

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Title
Biosynthesis of peptide inhibitor MR-387 by Streptomyces neyagawaensis
Author(s)
Myung Chul Chung; Choong Hwan Lee; Ho Jae Lee; Yung Hee Kho; Hyo Kon Chun
Bibliographic Citation
Biotechnology Letters, vol. 19, no. 7, pp. 607-610
Publication Year
1997
Abstract
Biosynthesis of MR-387 by Streptomyces neyagawaensis SL-387 was studied by testing the incorporation of radioactive precursors and the detection of biosynthetic enzyme. L-Phenylalanine, L-valine, L-proline, and acetic acid were efficiently incorporated into MR-387, but phenylethylamine and oxalic acid were not. These results suggest that the (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid moiety of MR-387 is synthesized from phenylalanine and acetic acid but not directly via the phenylethylamine. Synthesis of MR-387 is mediated by a peptide synthetase with a novel activity.
ISSN
0141-5492
Publisher
Springer
DOI
http://dx.doi.org/10.1023/A:1018318210644
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > SME Support Center > 1. Journal Articles
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