Synergistic stimulation of fibrinogen gelation by casein kinase II and polycationic compounds

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Title
Synergistic stimulation of fibrinogen gelation by casein kinase II and polycationic compounds
Author(s)
Kyoungho Suk; Jin Young Lee; Seung Ho Kim
Bibliographic Citation
Biochemistry and Molecular Biology International, vol. 42, no. 3, pp. 487-495
Publication Year
1997
Abstract
The processes of thrombin-induced gelation of the fibrinogen may be influenced by a variety of factors including phosphorylational state of the fibrinogen. Casein kinase II (CKII) has been shown to phosphorylate fibrinogen in vitro and accelerate gelation of the fibrinogen. In this work, we have demonstrated that CKII and polycationic compounds such as polylysine, spermine, and spermidine synergistically stimulate thrombin-induced gelation of the fibrinogen. These polycationic compounds were also found to increase the stimulatory effects of CKII on the platelet aggregation. Current findings suggest potential role of CKII and polycationic compounds in the process of hemostasis.
Keyword
casein kinase IIpolycationic compoundfibrinogenhemostasis
ISSN
1039-9712
Publisher
Wiley
DOI
http://dx.doi.org/10.1080/15216549700202891
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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