Expression of galectin-1 mRNA in the mouse uterus is under the control of ovarian steroids during blastocyst implantation

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Title
Expression of galectin-1 mRNA in the mouse uterus is under the control of ovarian steroids during blastocyst implantation
Author(s)
Young S Choe; Chang Seob Shim; Dong Chan Choi; Chul Sang Lee; Kyung Kwang Lee; Kyungjin Kim
Bibliographic Citation
Molecular Reproduction and Development, vol. 48, no. 2, pp. 261-266
Publication Year
1997
Abstract
Galectin-1 is a member of β-galactoside-binding lectins expressed in a variety of mammalian tissues. We report here that galectin-1 mRNA is abundantly expressed in the mouse reproductive organs such as the uterus and ovary. Uterine expression of galectin-1 mRNA is specifically regulated in the embryonic implantation process. Its expression increased at a high level on the fifth day post coitum (dpc 5) when embryos hatched into the endometrial epithelial cells. In the absence of embryos, however, galectin-1 expression in the mouse uterus decreased on dpc 5. In the delayed implantation mice, galectin-1 mRNA level was augmented by the termination of the delay of implantation. Ovarian steroids progesterone and estrogen differentially regulated galectin-1 mRNA level in uterine tissues. Treatment with RU486, e progesterone receptor antagonist, blocked progesterone-induced galectin-1 mRNA level in uterine tissues of ovariectomized mouse. ICI182780, a pure estrogen receptor antagonist, clearly blocked the estrogen effect. Taken together, galectin-1 gene expression in the uterine tissues was regulated by ovarian steroids and this regulation correlated with the implantation process.
Keyword
galectin-1implantation17β-estradiolprogesteroneanti-steroidsgene regulation
ISSN
1040-452X
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/(SICI)1098-2795(199710)48:2<261::AID-MRD14>3.0.CO;2-0
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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