Antifungal activities of magainin-2 hybrid peptides against Trichosporon beigelii

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Title
Antifungal activities of magainin-2 hybrid peptides against Trichosporon beigelii
Author(s)
Dong Gun Lee; Song Yub Shin; Sung Gu Lee; Kil Lyong Kim; Myung Kyu Lee; Kyung Soo Hahm
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 7, no. 1, pp. 49-51
Publication Year
1997
Abstract
In order to obtain a synthetic peptide with a more potent antifungal activity than magainin-2 but without hemolytic activity, four hybrid peptides were designed from the sequences of magainin 2 and cecropin A and their antifungal activities against Trichosporon beigelii were investigated. The result showed that analogue 2 and 4 exhibited better antifungal activity against T. beigelii than magainin-2 but no hemolytic activities. The peptides, therefore, could be used as models for the development of potent antifungal peptides.
Keyword
Magainin-2Trichosporon beigelitHybrid synthetic peptidesAntifungal activity
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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