DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song Yub Shin | - |
dc.contributor.author | Myung Kyu Lee | - |
dc.contributor.author | Kil Lyong Kim | - |
dc.contributor.author | Kyung Soo Hahm | - |
dc.date.accessioned | 2017-04-19T08:54:50Z | - |
dc.date.available | 2017-04-19T08:54:50Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 1397-002X | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/4199 | - |
dc.description.abstract | The hybrid peptide (CA-ME) derived from cecropin A(1-8) and melittin(1- 12) has potent antibacterial and antimalarial activities. Because the N- terminal sequence 1-12 of magainin 2 is similar to melittin(1-12), CA-MA with CA(1-8) and MA(1-12) and their analogues were designed and synthesized. Antitumor activities of these peptides were evaluated using three small cell lung cancer cell lines. Greater antitumor activity was observed when the residues 16, 18 and 19 of the peptide were hydrophobic (Leu or Val), basic (Lys) and basic (Lys), respectively. The IC50 values of the peptides with the residues were 2 to 4 μM. Residue 12 was related to hemolytic activity rather than antitumor activity. Increase in amphipathicity of P4 enhanced hemolytic activity without significant change in antitumor activity. The α- helicity of the peptides in a 30 nm sodium dodecyl sulfate solution was more closely correlated to hemolytic activity than antitumor activity. | - |
dc.publisher | Wiley | - |
dc.title | Structure-antitumor and hemolytic activity relationships of synthetic peptides derived from cecropin A-magainin 2 and cecropin A-melittin hybrid peptides | - |
dc.title.alternative | Structure-antitumor and hemolytic activity relationships of synthetic peptides derived from cecropin A-magainin 2 and cecropin A-melittin hybrid peptides | - |
dc.type | Article | - |
dc.citation.title | Chemical Biology & Drug Design | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 285 | - |
dc.citation.startPage | 279 | - |
dc.citation.volume | 50 | - |
dc.contributor.affiliatedAuthor | Song Yub Shin | - |
dc.contributor.affiliatedAuthor | Myung Kyu Lee | - |
dc.contributor.affiliatedAuthor | Kil Lyong Kim | - |
dc.contributor.affiliatedAuthor | Kyung Soo Hahm | - |
dc.contributor.alternativeName | 신송엽 | - |
dc.contributor.alternativeName | 이명규 | - |
dc.contributor.alternativeName | 김길룡 | - |
dc.contributor.alternativeName | 함경수 | - |
dc.identifier.bibliographicCitation | Chemical Biology & Drug Design, vol. 50, pp. 279-285 | - |
dc.subject.keyword | Hybrid peptides | - |
dc.subject.keyword | antitumor activity | - |
dc.subject.keyword | hemolytic activity | - |
dc.subject.keyword | α-helicity | - |
dc.subject.local | Hybrid peptide | - |
dc.subject.local | Hybrid peptides | - |
dc.subject.local | hybrid peptide | - |
dc.subject.local | anti-tumor activity | - |
dc.subject.local | antitumor activity | - |
dc.subject.local | Antitumor activity | - |
dc.subject.local | Hemolytic activity | - |
dc.subject.local | hemolytic activity | - |
dc.subject.local | α-helicity | - |
dc.description.journalClass | Y | - |
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