Immunosuppressive characteristics of oligomycin derivatives produced by Streptomyces lydicus MCY-524

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Title
Immunosuppressive characteristics of oligomycin derivatives produced by Streptomyces lydicus MCY-524
Author(s)
Sang Yong Lee; Sang Bae Han; Hang Sub Kim; Young Ho Kim; Hwan Mook Kim; Chang Jin Kim; Soon-Duk Hong; Jung Joon Lee
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 7, no. 1, pp. 56-61
Publication Year
1997
Abstract
A strain producing immunosuppressive substances was isolated from a soil in Cheju island. By morphological, cultural, and physiological studies, the strain was identified as Streptomyces lydicus MCY-524. Cultured broth was purified by silica gel, sephadex LH-20 and preparative HPLC and gave two immunosuppressive compounds, MCH-22 and MCH-32. They dramatically suppressed the B cell activation with lipopolysaccharide, T cell activation by mixed lymphocyte response, and primary T-dependent antibody response at a final concentration of 1 μg/ml. They also markedly suppressed the proliferation of lymphocytes induced by lipopolysaccharide, pokeweed mitogen, and concanavaline A at the same concentration. Their suppressive activities, which were comparable to those of cyclosporin A, suggested that they were potent and broad immunotoxic agents on the immune functions of murine lymphocytes.
Keyword
Homooligomycin EImmunosuppressant activitiesStreptomyces lydicus
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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