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- Title
- Immunosuppressive characteristics of oligomycin derivatives produced by Streptomyces lydicus MCY-524
- Author(s)
- Sang Yong Lee; Sang Bae Han; Hang Sub Kim; Young Ho Kim; Hwan Mook Kim; Chang Jin Kim; Soon-Duk Hong; Jung Joon Lee
- Bibliographic Citation
- Journal of Microbiology and Biotechnology, vol. 7, no. 1, pp. 56-61
- Publication Year
- 1997
- Abstract
- A strain producing immunosuppressive substances was isolated from a soil in Cheju island. By morphological, cultural, and physiological studies, the strain was identified as Streptomyces lydicus MCY-524. Cultured broth was purified by silica gel, sephadex LH-20 and preparative HPLC and gave two immunosuppressive compounds, MCH-22 and MCH-32. They dramatically suppressed the B cell activation with lipopolysaccharide, T cell activation by mixed lymphocyte response, and primary T-dependent antibody response at a final concentration of 1 μg/ml. They also markedly suppressed the proliferation of lymphocytes induced by lipopolysaccharide, pokeweed mitogen, and concanavaline A at the same concentration. Their suppressive activities, which were comparable to those of cyclosporin A, suggested that they were potent and broad immunotoxic agents on the immune functions of murine lymphocytes.
- Keyword
- Homooligomycin EImmunosuppressant activitiesStreptomyces lydicus
- ISSN
- 1017-7825
- Publisher
- Korea Soc-Assoc-Inst
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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