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- Title
- Immunosupressive activity of elaiophylins
- Author(s)
- Sang Yong Lee; Hang Sub Kim; Young Ho Kim; Sang Bae Han; Hwan Mook Kim; Soon-Duck Hong; Jung Joon Lee
- Bibliographic Citation
- Journal of Microbiology and Biotechnology, vol. 7, no. 4, pp. 272-277
- Publication Year
- 1997
- Abstract
- In the purification of elaiophylin from a culture of Streptomyces hygroscopicus MCY-846, mono- and dimethyl-elaiophylin were obtained through a O-methylation of the hemiketal hydroxy group of elaiophylin. All the three elaiophylins showed cytotoxicity against several human tumor cell lines and murine cell lines. Elaiophylin and monomethyl-elaiophylin also showed antimicrobial activities against gram-positive bacteria and potent inhibitory effects on the activation of B cells by lipopolysaccharide as well as on the proliferation of mouse splenic lymphocytes stimulated by mitogens but dimethyl-elaiophylin did not. This result indicats that elaiophylin and monomethyl-elaiophylin would be strong immunosuppressants. Furthermore this result revealed an interesting structure-activity relationship suggesting that the lack of symmetry and /or the free OH group at C-11 of elaiophylin might be important in conferring biological activities.
- Keyword
- ElaiophylinImmunosupressiveStreptomyces hygroscopicus MCY846
- ISSN
- 1017-7825
- Publisher
- Korea Soc-Assoc-Inst
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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