Platelet activating factor antagonist activity of ginsenosides

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Title
Platelet activating factor antagonist activity of ginsenosides
Author(s)
Keun Young Jung; Dong Seon Kim; Sei Ryang Oh; Im Seon Lee; Jung Joon Lee; Jong Dae Park; Shin Il Kim; Hyeong Kyu Lee
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 21, no. 1, pp. 79-80
Publication Year
1998
Abstract
Ginseng saponins and their degradation products have been screened for antagonist activity towards [3H]PAF (platelet activating factor) in washed rabbit platelet receptor binding studies. 20(S)- and Δ20-ginsenosides Rg3, protopanaxadiol-type saponins, were found to be relatively potent PAF antagonists (IC50=4.9 x 10-5 M and 9.2 x 10-5 M, respectively).
Keyword
20(S)-ginsenoside Rg3* D20- ginsenosides Rg3, Δ20-ginsenoside Rg.PAE antagonistic activityPanax ginseng
ISSN
0918-6158
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/bpb.21.79
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
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