Platelet-activating factor antagonistic activity and 13C NMR assignment of pregomisin and chamigrenal from Schisandra chinensis

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Title
Platelet-activating factor antagonistic activity and 13C NMR assignment of pregomisin and chamigrenal from Schisandra chinensis
Author(s)
Im Seon Lee; Keun Young Jung; Sei Ryang Oh; Dong Seon Kim; Jung Hee Kim; Jung Joon Lee; Hyeong Kyu Lee; Seung Ho Lee; Eun Hee Kim; Chaejoon Cheong
Bibliographic Citation
Archives of Pharmacal Research, vol. 20, no. 5, pp. 633-636
Publication Year
1997
Abstract
In the course of searching for PAF receptor antagonists, pregomisin (1) and chamigrenal (2) were isolated from the fruits of Schizandra chinensis Baill by the bioactivity-guided isolation. Both compounds showed PAF antagonistic activity and the IC50 values were 4.8×10-5 M and 1.2×10-4 M, respectively. In addition, the 13C NMR assignments of 1 and 2 using DEPT, HMQC, COLOC and HMBC were reported for the first time.
Keyword
Schisandra chinensis BaillSchisandraceaePAF receptor antagonistpregomisinchamigrenal13C NMR
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02975223
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
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