Platelet-activating factor antagonistic activity and 13C NMR assignment of pregomisin and chamigrenal from Schisandra chinensis
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- Title
- Platelet-activating factor antagonistic activity and 13C NMR assignment of pregomisin and chamigrenal from Schisandra chinensis
- Author(s)
- Im Seon Lee; Keun Young Jung; Sei Ryang Oh; Dong Seon Kim; Jung Hee Kim; Jung Joon Lee; Hyeong Kyu Lee; Seung Ho Lee; Eun Hee Kim; Chaejoon Cheong
- Bibliographic Citation
- Archives of Pharmacal Research, vol. 20, no. 5, pp. 633-636
- Publication Year
- 1997
- Abstract
- In the course of searching for PAF receptor antagonists, pregomisin (1) and chamigrenal (2) were isolated from the fruits of Schizandra chinensis Baill by the bioactivity-guided isolation. Both compounds showed PAF antagonistic activity and the IC50 values were 4.8×10-5 M and 1.2×10-4 M, respectively. In addition, the 13C NMR assignments of 1 and 2 using DEPT, HMQC, COLOC and HMBC were reported for the first time.
- ISSN
- 0253-6269
- Publisher
- Pharmaceutical Soc Korea
- Full Text Link
- http://dx.doi.org/10.1007/BF02975223
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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