Open Access@KRIBBDivision of A.I. & Biomedical ResearchImmunotherapy Research Center1. Journal Articles
Cloning of the human cDNA sequence encoding the NADH : ubiquinone oxidoreductase MLRQ subunit
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- Title
- Cloning of the human cDNA sequence encoding the NADH : ubiquinone oxidoreductase MLRQ subunit
- Author(s)
- Jae Wha Kim; Yong Hee Lee; Ho Bum Kang; Young Kyung Choe; Tae Wha Chung; Sung Yeoul Chang; Kwang Soo Lee; In Seong Choe
- Bibliographic Citation
- Biochemistry and Molecular Biology International, vol. 43, no. 3, pp. 669-675
- Publication Year
- 1997
- Abstract
- A cDNA clone encoding human NADH:ubiquinone oxidoreductase (complex I of mitochondrial respiratory chain) MLRQ subunit was isolated from human fetal liver cDNA library. The clone contained an open reading frame of 246 bp which predicted a protein comprising 81 amino acids with a calculated molecular weight of 9370 Da. The deduced amino acid sequence exhibited 95% homology (88% identity and 7% favored substitution) to that of bovine MLRQ subunit. Northern analysis revealed that the cDNA clone hybridized with a 0.7 kb mRNA species which was present in all tissues examined. The expression level of the 0.7 kb mRNA in heart, skeletal muscle, and brain was higher than in other organs. Human MLRQ cDNA could cross-hybridize with the genomic DNAs from various species.
- Keyword
- NADH:ubiquinone oxidoreductaseMitochondrial respiratory chainMLRQ subunitcDNA sequenceTissue distribution(Human)
- ISSN
- 1039-9712
- Publisher
- Wiley
- Full Text Link
- http://dx.doi.org/10.1080/15216549700204471
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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