Streptomyces 배양액에서의 interleukin-1 유사물질의 동정

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dc.contributor.authorMyoung Soo Nam-
dc.contributor.authorYun Soo Bae-
dc.contributor.authorDo Young Yoon-
dc.contributor.authorKyung Soo Nam-
dc.contributor.authorIn Seong Choe-
dc.contributor.authorTai Wha Chung-
dc.date.accessioned2017-04-19T08:55:16Z-
dc.date.available2017-04-19T08:55:16Z-
dc.date.issued1993-
dc.identifier.issn0257-2389-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4353-
dc.description.abstractWe have identified a T cell-activating material in the culture supernatant of Streptomyces species. The factor in microbial culture supernatant (MCS) induced thymocyte proliferation in a dose dependent fashion and it could be detected by immunoblot analysis using anti-interleukin1(IL-1) antibody. The factor in MCS was slightly larger(about 21 kd) in its molecular weight than IL-1 on SDS-PAGE. When ^125I-MCS was covalently coupled with homo-bifunctional cross-linking agent, disuccinimidyl-propionate to IL-1 receptor(IL-1R) on mouse thymoma cell(EL-4) and immunoprecipitated with anti-IL-1R antibody the molecular weight of this complex of 110 kd was observed. Interaction between IL-1 receptor and the factor in MCS could be inhibited by addition of excess IL- lβ. These results suggest that Streptomyces species may produce a factor which is closely related to IL-1β in its functional and biochemical characteristics.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleStreptomyces 배양액에서의 interleukin-1 유사물질의 동정-
dc.title.alternativeIdentification of interleukin-1 like material in Streptomyces culture supernatant-
dc.typeArticle-
dc.citation.titleKorean Journal of (Applied) Microbiology & Biotechnology-
dc.citation.number2-
dc.citation.endPage149-
dc.citation.startPage144-
dc.citation.volume21-
dc.contributor.affiliatedAuthorDo Young Yoon-
dc.contributor.affiliatedAuthorIn Seong Choe-
dc.contributor.affiliatedAuthorTai Wha Chung-
dc.contributor.alternativeName남명수-
dc.contributor.alternativeName배윤수-
dc.contributor.alternativeName윤도영-
dc.contributor.alternativeName남경수-
dc.contributor.alternativeName최인성-
dc.contributor.alternativeName정태화-
dc.identifier.bibliographicCitationKorean Journal of (Applied) Microbiology & Biotechnology, vol. 21, no. 2, pp. 144-149-
dc.subject.keywordInterleukin-1-
dc.subject.keywordmicrobial culture supernatant (MCS)-
dc.subject.keywordthymocyte proliferation-
dc.subject.localInterleukin-1-
dc.subject.localinterleukin-1-
dc.subject.localmicrobial culture supernatant (MCS)-
dc.subject.localthymocyte proliferation-
dc.description.journalClassN-
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